As a Beta and an assistant professor of genetics, Im Hansol is blindsided by devastating news: his advising professor is resigning due to poor health. Luckily, he secures a glowing recommendation for a new assistant professor role at a different university.

The next day, Hansol arrives at the Korean University Economics Department for his interview and is greeted by the sight of the exiting candidates, their faces bleached with terror. Worried, but compelled by curiosity, Hansol steps into the office. He's momentarily baffled by the professor's handsome looks and impeccable charm.

But the confusion lasts only a second. The hiring professor, Kang Daehan, abruptly slams Hansol against the wall and begins to inhale his scent.

Mr. Beta follows the tumultuous campus romance between Kang Daehan, the Dominant Alpha with the presence of a giant dog, and the perfectly ordinary Beta, Im Hansol!